Scientific Insights
Know Your DNA
DNA is the basic genetic material to all the living things. Human DNA sequence is about 99.5% identical between two persons, but their appearance, behaviour, health condition can be different. In other words, the small differences in the DNA sequence makes each person unique.
These differences are called genetic variants. Your DNA was passed down from your parents. Genetic variations are scientifically studied to provide insights which are related to health conditions, traits etc.
What your genes can tell you
Genetic variations in our genes are partially responsible for common diseases such as heart disease, diabetes, etc. A genetic variation along with lifestyle and environmental changes can raise your chances of getting common diseases. Scientific research has shown that up to 80% of the risk for developing certain diseases may be explained by genetics. However. this must be correlated with your age, diet, body weight, ethnicity, and other factors. For example, an unhealthy diet and lifestyle can contribute to higher BMI which can make you obese, but at the same time obesity can run in certain families.
Knowing your genetic predisposition for genetically developing a health condition can help you make the right choices for better health.
Polygenic Risk Score (PRS) for disease risk prediction
Genomic research over the past two decades has revealed that our risk for many common conditions such as heart disease or diabetes are not influenced by just one genetic variant, or even a handful of them. Instead, multiple genes work in tandem to influence our risk for diseases. There are millions of genetic variations, with independent minor effects that have a combined influence on your chance of developing a disease.
Polygenic Risk Score quantifies the contributing effects of a large number of genetic variations into a score and estimates whether the tested individual is at a high, moderate or average risk of getting a specific disease. PRS is a scientifically established and validated methodology, published in peer-reviewed journals.
Genessense Polygenic Risk Scores are validated in the South Asian population.
Our Scientists have invested over 10000 + man hours on research and validation to design and develop the Genessense Genomic Wellness Services.
Coronary Artery Disease (CAD)
Cohort of about 3000 case-control samples. Study is published.1.3 million
genetic markers covered
Type 2 Diabetes (T2DM)
Cohort of about 11000 case-control samples from 3 independent cohorts. The study manuscript is in the process of getting published.6.9 million
genetic markers covered
Obesity/BMI
Cohort of 14000 individuals from 3 independent cohorts. The study manuscript is in the process of getting published.2 million
genetic markers covered
Hypertension
Cohort of about 2700 case-control samples. The study manuscritpt is in the process of getting published.10000
genetic markers covered
Parkinson's Disease (PD)
Cohort about 2000 case-control samples. The pilot study is published.1805
genetic markers covered
Age-related Macular Degeneration (AMD)
Cohort about 600 case-control samples. The study manuscript is in the process of getting published.34
genetic markers coveredGenessense Advantage
Genessense by MedGenome has been a front-runner in this area, by collaborating with renowned clinical experts in their respective fields, recruiting samples from the South Asian population, performing additional validation studies, and publishing high-quality scientific results.
Existing risk predictions are based on factors such as weight, lifestyle, blood measurements which are variable throughout a person’s lifetime and cannot be used to predict genetic risk accurately. Genessesne screenings on the other hand is an independent genetic predictor and is free from variabilities. These screenings are based on a person’s genetic makeup and predicts their risk profile.
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pre and post genetic screening to understand better.
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